Rhodopsin and Its Mutants
Created on July 27|Last edited on July 27
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Notice the altered folding of the red region (C-terminal?) in the two mutants (second row) compared to the "wildtype" variant (top row).
In the wildtype, the red region is folded into an alpha helix, which sticks out from the main body of the protein, while in the mutants, this region does not have as much helical character (especially in the P23H mutant) and is tucked on top of the other transmembrane domains.
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Rhodopsins
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The region with the difference is where the G-protein complex binds during visual phototransduction.
A structure from a bovine rhodopsin appears below. Notice that the red section (following the alpha helix labeled VII) is more akin to the non-helical structure observed in the predicted mutant structures.
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